Triterpenoids from the spores of Ganoderma lucidum
نویسندگان
چکیده
منابع مشابه
Antiinflammatory triterpenoids and steroids from Ganoderma lucidum and G. tsugae.
The antiinflammatory properties of triterpenoids and steroids from both Ganoderma lucidum and Ganoderma tsugae were studied. Twelve compounds, including ergosta-7,22-dien-3beta-ol (1), ergosta-7,22-dien-3beta-yl palmitate (2), ergosta-7,22-dien-3-one (3), ergosta-7,22-dien-2beta,3alpha,9alpha-triol (4), 5alpha,8alpha-epidioxyergosta-6,22-dien-3beta-ol (5), ganoderal A (6), ganoderal B (7), gano...
متن کاملAnti-androgenic activities of the triterpenoids fraction of Ganoderma lucidum
The ethanol extract of Ganoderma lucidum showed inhibitory activity on both isozymes (types 1 and 2) of 5a-reductase and suppression effects of ventral prostate growth induced by testosterone in castrated rat, but not induced by dihydrotestosterone. Activity-guided fractionation and TLC analysis suggested that the active principles in vivo were triterpenoids. These results indicate that the tri...
متن کاملMolecular identification of Ganoderma lucidum from Iran
Medicinal mushroom Ganoderma lucidum has been used in East Asia for centuries in order to prevent and treat a variety of diseases such as hepatitis, immunological disorders and cancers. In fact, this fungus contains a vast source of polysaccharides, proteins and secondary metabolites with anti-tumor and immuno-modulatory properties. Up to now, a variety of drug metabolites extracted from G. luc...
متن کاملCytotoxic lanostane-type triterpenoids from the fruiting bodies of Ganoderma lucidum and their structure–activity relationships
We conducted a study of Ganoderma lucidum metabolites and isolated 35 lanostane-type triterpenoids, including 5 new ganoderols (1-5). By spectroscopy, we compared the structures of these compounds with known related compounds in this group. All of the isolated compounds were assayed for their effect against the human breast carcinoma cell line MDA-MB-231 and hepatocellular carcinoma cell line H...
متن کاملStructure-activity relationship for inhibition of 5alpha-reductase by triterpenoids isolated from Ganoderma lucidum.
In humans, 5alpha-reductase is involved in the development of benign prostatic hyperplasia. Triterpenoids isolated from ethanol extracts of Ganoderma lucidum (Fr.) Krast (Ganodermataceae) inhibited 5alpha-reductase activity. The presence of the C-3 carbonyl group and of the C-26-alpha,beta-unsaturated carbonyl group was characteristic of almost all inhibitors isolated from G. lucidum.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: North American Journal of Medical Sciences
سال: 2011
ISSN: 1947-2714
DOI: 10.4297/najms.2011.3495